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Título : | A NewSynthetic Route of 2-Aroyl- and 2-Benzyl-Benzofurans and their Application in the Total Synthesis of a Metabolite Isolated from Dorstenia gigas |
Autor : | Cruz López, María del Carmen |
Palabras clave : | Dorstenia gigas |
Fecha de publicación : | 30-ene-2013 |
Resumen : | The Lewis acid-catalyzed cyclization of the (Z)-3-(dimethylamino)-2-aryloxy-1-arylprop-2-en-1-ones 4a–h leads to a regioselective and short synthesis of 2-aroylbenzofurans 2a–h. TheWolff–Kishner reduction of the latter yielded a series of substituted 2-benzylbenzofurans 3a–h. This methodology was applied in the first total synthesis of the metabolite 2-(4-hydroxybenzyl)-6-methoxybenzofuran 1, which was isolated from the tropical plant Dorstenia gigas, and obtained through a six-step route and in a 24% overall yield. |
Descripción : | A NewSynthetic Route of 2-Aroyl- and 2-Benzyl-Benzofurans and their Application in the Total Synthesis of a Metabolite Isolated from Dorstenia gigas |
URI : | http://www.repositoriodigital.ipn.mx/handle/123456789/12369 |
Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Art_Aus J Chem 2008, 61(12), 991-999-1a.pdf | 92.26 kB | Adobe PDF | Visualizar/Abrir |
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