HAPLOTIPOS CD1d Y SU RELACION TOPOGRAFICA CON EL INFARTO AGUDO DEL MIOCARDIO ANTERIOR

Abstract

Introduction: Ischemic heart disease by coronary atherosclerosis is the leading cause of death in adults over 20 years of age in Mexico. The consequences of this entity are devastating, is a cause of disability and impaired functional class of survivors. In the country the second leading cause of death is ischemic heart disease, where nearly 80% occur in patients over 60 years, 20% after 85 years and of these a l5% and 30% die within 30 days. Ischemic heart disease remains the single largest cause of death and estimates suggest it will be the leading cause of death worldwide in 2020. Genetic polymorphisms are being considered as new risk factors for coronary atherosclerosis, hypertension, smoking and diabetes. Recently, NKT cells, a specialized subtype of T lymphocytes that recognize glycolipid antigens by CD1 proteins has been reported as accelerating atherosclerosis. CD1d proteins have been identified in atherosclerotic plaques and its expression has been localized in areas of infiltration of T lymphocytes, suggesting a functional association between molecule CD1d, antigen-presenting lipid and NKT cells in the lesions. Objective: In this paper the main objective was to establish the topographical relationship of anterior myocardial infarction with CD1d haplotypes. Material and Methods: A prospective clinical study, observational and descriptive in the adult emergency department Regional Hospital Adolfo López Mateos ISSSTE, in a period January 2009 to December 2010, which included 121 patients male and female over 35 years of age who had acute myocardial infarction, in which they were subjected to a study to identify the haplotype CD1d. Results: This study found a population of 121 patients with acute myocardial infarction, with a mean age (61.5), and a gender ratio of 46% in women and 54% in men, the total population were infracted 45 patients (37%) with the haplotypes 7 Hap1/Hap2, where the infarcted area is the most common anterior face (44%), hypercholesterolemia in 56% and hypertriglyceridemia in 66% of cases. Conclusions: We concluded that there is an association between acute anterior myocardial infarction and haplotype CD1d (association Hap1/Hap2).