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Título : | ANewSynthetic Route of 2-Aroyl- and 2-Benzyl-Benzofurans and their Application in the Total Synthesis of a Metabolite Isolated from Dorstenia gigas |
Autor : | Jiménez Montejo, Fabiola Eloísa |
Palabras clave : | 2-Aroyl- and 2-Benzyl-Benzofurans |
Fecha de publicación : | 26-feb-2013 |
Resumen : | The Lewis acid-catalyzed cyclization of the (Z)-3-(dimethylamino)-2-aryloxy-1-arylprop-2-en-1-ones 4a–h leads to a regioselective and short synthesis of 2-aroylbenzofurans 2a–h. TheWolff–Kishner reduction of the latter yielded a series of substituted 2-benzylbenzofurans 3a–h. This methodology was applied in the first total synthesis of the metabolite 2-(4-hydroxybenzyl)-6-methoxybenzofuran 1, which was isolated from the tropical plant Dorstenia gigas, and obtained through a six-step route and in a 24% overall yield. |
Descripción : | Article |
URI : | http://www.repositoriodigital.ipn.mx/handle/123456789/13815 |
Aparece en las colecciones: | Congresos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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6. Aus J Chem 2008, 61(12), 991-999.pdf | 143.62 kB | Adobe PDF | Visualizar/Abrir |
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