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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Alvarez Fitz, Patricia | - |
dc.date.accessioned | 2013-02-19T08:12:46Z | - |
dc.date.available | 2013-02-19T08:12:46Z | - |
dc.date.issued | 2013-02-19 | - |
dc.identifier.uri | http://www.repositoriodigital.ipn.mx/handle/123456789/13206 | - |
dc.description | http://www.mdpi.com/1420-3049/17/7/8464 | es |
dc.description.abstract | Biotransformation processes have been successfully utilized to obtain products of pharmaceutical, chemical, food, and agricultural interest, which are difficult to obtain by classic chemical methods. The compound with antituberculous activity, 9-methoxy-tariacuripyrone (1), isolated from Aristolochia brevipes, was submitted to biotransformation with the yeast Saccharomyces cerevisiae under culture, yielding 5-amino-9-methoxy-3,4-dihydro-2H-benzo[h]chromen-2-one (2). The structure of 2 was elucidated on the basis of spectroscopic analyses. The results mainly show the reduction of the double bond and the nitro group of compound 1. Metabolite 2 demonstrated an increase in anti-tuberculous activity (MIC = 3.12 μg/mL) against the drug-sensitive Mycobacteriumtuberculosis (H37Rv) strain, with respect to that shown by 1. | es |
dc.language.iso | en | es |
dc.title | ENZYMATIC REDUCTION OF 9-METHOXYTARIACURIPYRONE BY SACCHAROMYCES CEREVISIAE AND ITS ANTIMYCOBACTERIAL ACTIVITY. | es |
dc.type | Article | es |
dc.description.tipo | es | |
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