Estado oxidante-antioxidante en eritrocitos de pacientes con Enfermedad Pulmonar Obstructiva Crónica. “Efecto de contaminantes de la Atmósfera Material Partículado 2.5”

Abstract

The patients with COPD, present/display as she leaves from his suffering an increase in the production of reactive species of I oxygenate/nitrogen ROS/RNS originated in different weaves involved in the suffering. The reactive molecule generation is concomitant to the diminution in the efficiency of the systems antioxidants, originating a metabolic condition that causes a metabolic imbalance denominated oxidating stress. As a result of oxidating stress structural modifications appear and functional in practically all the weaves including the erythrocytes in which there is a diminution in the capacity to transport and to spread oxygen towards weaves, because the hemoglobina, presents/displays one diminished capacity of oxygenation by its change of potential redox oxidizing to the ferrous state (metahemoglobina) the union of oxygen with the hemoglobina is cooperative and is affected by diverse factors, eg: alostericos temperature, pH and some effectors (2,3-bisfosfoglicerato) to avoid the inactivity of the hemoglobina (Hb) due to the change redox, the erythrocyte counts on an efficient reducing machinery, that is a process that it avoids oxidation of the Hb and requires of the arranged oxidation of the glutatión reduced (L-γ-glutamyl-L-cisteinyl-gycine GSH) to oxidized glutatión (GSSG), and the process of reduction of this last molecule requires the availability of the NADPH+H generated by the way of pentoses. On the other hand the erythrocyte needs to maintain the integrity of its membrane sustained in the catalytic function of the proteins that conform denominated band 3; constituted by the added protein major shrunk in the membrane and that given its structure, also is susceptible to be affected by oxidating stress during the COPD.