Por favor, use este identificador para citar o enlazar este ítem: http://repositoriodigital.ipn.mx/handle/123456789/8538
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.contributor.advisorLares Assef, Ismael-
dc.contributor.authorReyes Hernández, Octavio D.-
dc.contributor.authorLares Asseff, Ismael-
dc.contributor.authorSosa Macias, Martha-
dc.contributor.authorVega, Libia-
dc.contributor.authorAlbores, Arnulfo-
dc.contributor.authorElizondo, Guillermo-
dc.descriptionArtículo de Investigaciónes
dc.description.abstractCytochrome P-450 3A4 (CYP3A4) contributes to the metabolism of approximately half the drugs in clinical use today. The aim of the present study was to determine the frequency of the CYP3A4 * 1B , * 2 , * 4 , * 5 , and * 18 alleles amongst both Tepehuan Amerindians, a native group that has inhabited northern Mexico for thousands of years, and Mestizo Mexicans, and to compare the data with those of other populations. Genotyping experiments revealed that 8.8 and 8.0% of the Mestizo and Tepehuano subjects, respectively, carried the CYP3A4 * 1B allele. Only one Mestizo subject was heterozygous for the CYP3A4 * 2 variant, while CYP3A4 * 4 , * 5 and * 18 allelic variants were not detected in either group. On the other hand, the frequencies of the CYP3A4 * 1B variant in Mestizos and Tepehuanos were similar to those reported for Caucasians, but different from those observed for African and Asian populations.es
dc.subjectCytochrome P-450 3A4es
dc.titleA Comparative Study of CYP3A4 Polymorphisms in Mexican Amerindian and Mestizo Populationses
Aparece en las colecciones: Artículos

Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
1A Comparative Study of CYP3A4.pdf292.15 kBAdobe PDFVisualizar/Abrir

Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.