El Instituto Politécnico Nacional
Contribuye al desarrollo económico y social de la nación, a través de la formación integral de personas competentes; de la investigación, el desarrollo tecnológico y la innovación. Además tiene reconocimiento internacional por su calidad e impacto social.
Por favor, use este identificador para citar o enlazar este ítem:
http://repositoriodigital.ipn.mx/handle/123456789/11692Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.creator | Guevara-Salazar, Alberto | - |
| dc.creator | Quintana-Zavala, Delia | - |
| dc.creator | Espinoza-Fonseca, Michel | - |
| dc.creator | Correa-Basurto, Jose | - |
| dc.creator | Trijillo-Ferrara, Jose | - |
| dc.date | 2012-03-29T21:25:08Z | - |
| dc.date | 2012-03-29T21:25:08Z | - |
| dc.date | 2007-10-01 | - |
| dc.date.accessioned | 2013-01-16T16:41:59Z | - |
| dc.date.available | 2013-01-16T16:41:59Z | - |
| dc.date.issued | 2013-01-16 | - |
| dc.identifier | 1665-9686 | - |
| dc.identifier | http://hdl.handle.net/123456789/1225 | - |
| dc.identifier.uri | http://www.repositoriodigital.ipn.mx/handle/123456789/11692 | - |
| dc.description | A computational docking approach, in combination with the Hammett relationship, has been employed to evaluate the electronic influence of substituents on ligand binding and the active site-directed inhibitory potency on acetylcholinesterase using nine N-aryl-substituted succinimides. Our results indicate that electronwithdrawing groups attached to benzene moiety of the compounds favor the inhibitory potency while electron-donating groups do not. This fact was confirmed by performing kinetic experiments on acetylcholinesterase from Electrophorus electricus; the experiments showed that para-substituted-NO2 compound inhibits better than para-substituted-OMe and –H derivatives. This approach may be useful for the rationalization of drugs design, as well as the mechanism of the active site. | - |
| dc.description | Instituto Politecnico Nacional, CONACYT | - |
| dc.language | en | - |
| dc.publisher | Journal of the Mexican Chemical Society | - |
| dc.relation | ;51, 222-227 | - |
| dc.subject | Acetylcholinesterase | - |
| dc.subject | Hammett Relationship | - |
| dc.subject | Docking, | - |
| dc.subject | N-aryl-substituted-succinimides | - |
| dc.title | The Electronic Influence on the Active Site-Directed Inhibition of | - |
| dc.type | Article | - |
| Aparece en las colecciones: | Doctorado | |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| DQZ_J-Mex_Chem_Soc_2007_222_227.pdf | 615.66 kB | Adobe PDF | Visualizar/Abrir |
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.